earth’s climate has historically undergone numerous significant shifts
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Growth factors activate Ras to transduce proliferation signals. Not surprisingly, this protein is very often mutated leading to its hyperactivation in cancer. Ras mediates the activation of several effector pathways like PI3K and MAPK pathways.6, 7, 8 The PI3K pathway, which is also activated by growth factors, leads to increased glycolysis through several ways.
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A slower cooling rate will result in lower Tf, and the glassy state will become brittle if Tf drops below Tfc. Typical cooling rates that result in bulk metallic glass formation (thickness span over four orders of magnitude ranging from 0.1 to 1,000Ks1 (ref. 35).
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